IMMUNE INACTIVATION OF ANTI-SIMIAN IMMUNODEFICIENCY VIRUS CHIMERIC ANTIGEN RECEPTOR T CELLS IN RHESUS MACAQUES

Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques

Chimeric antigen receptor (CAR) T cell therapies are being investigated as potential HIV cures and designed to target HIV reservoirs.Monoclonal antibodies (mAbs) targeting the simian immunodeficiency virus (SIV) envelope allowed us to investigate the potency of single-chain variable fragment (scFv)-based anti-SIV CAR T cells.In vitro, CAR T cells e

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On the weak solution of a three-point boundary value problem for a class of parabolic equations with energy specification

This paper deals with weak solution in weighted Sobolev spaces, of three-point boundary value problems which combine Dirichlet and integral conditions, for linear and quasilinear parabolic equations in a domain Gift Cards with curved lateral 147 boundaries.We, firstly, prove the existence, uniqueness, and continuous dependence of the solution for t

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